ABSTRACT
Background: fetal growth restriction [FGR] is a condition with heterogeneous pathophysiology which characterized by fetal weight less than the tenth percentile for gestational age. Several factors have impact on maternal, placental and fetal due to growth restriction
Objective: the aim of this study was to investigate the relationship between levels of leptin in the cord, and serum leptin of mother's also abnormal color Doppler indices of umbilical artery with fetal growth restriction
Materials and Methods: this is a cross sectional study conducted in Isfahan, Iran, 2015-2016. We recruited 40 women with singleton pregnancies complicated by fetal growth restriction [Group I] and 40 pregnant women with normal fetal growth [Group II] with matched age. Maternal serum and umbilical artery leptin levels were determined with Enzyme-Linked immunosorben method. Also, color Doppler ultrasound of umbilical artery was performed
Results: mean maternal and fetal leptin levels were lower in the FGR group compared to the normal group [36.58+/-[20.99] and 7.42 +/-[4.08]vs. 47.32+/-[22.50] and 30.49+/-[14.50] respectively]. Also, mean fetal leptin level was lower in the group with abnormal color Doppler sonographic indices compared to the normal group [7. 40 +/- [4.10] vs 27.06+/- [15.80], respectively]
Conclusion: this study indicated that maternal and fetal leptin levels are correlated with FGR originating from damaged placental function; also fetal leptin level can indicate changes in color Doppler sonographic indices
ABSTRACT
Celiac disease is an autoimmune disorder that affected 1% of all population in United State. Classic manifestations of disease consist of early childhood diarrhea, malabsorption, steatorrhea and growth retardation but disease can affects adult at any age. In adult anemia is a more frequent finding. This patient was a 40-year-old lady with progressive fatigue and lower extremities pitting edema. Iron deficiency anemia and celiac disease were diagnosed on the basis of low serum ferritin, elevated serum level of IgA endomysial and tissue transglutaminase anti-bodies and histologic findings in small bowel biopsies. Pericardial effusion in her evaluation was detected incidentally. Asymptomatic pericardial effusion in this patient was only detectable with imaging. After starting of gluten free diet and iron supplement fatigue, peripheral edema and pericardial effusion on echocardiography decreased. It should be noted that asymptomatic pericardial effusion may be seen in adults with celiac disease
Subject(s)
Humans , Female , Celiac Disease , Anemia, Iron-Deficiency , Fatigue , EdemaABSTRACT
The aim of this study was to compare CD10 expression in tumoral and stromal cells of cutaneous squamous cell carcinoma [SCC] and basal cell carcinoma [BCC] in order to differentiate SCC from BCC in problematic cases. Twenty six SCC and 30 BCC cases were retrieved randomly from Al-zahra hospital pathology archive and CD10 expression was determined in tumoral and stromal cells [fibroblasts around tumoral nests] of each case based on immunohistochemical method. 25 of 26 SCC samples [96.2%] failed to stain with CD10 in tumoral cells whereas CD10 expression of stromal cells was identified in all SCC cases [100%]. In contrast, 26 of 30 BCC cases [86.7%] were positive in tumoral cells and only 5 of 30 BCC samples [17.7%] were positive in stromal cells. Accordingly, the staining pattern of tumoral and stromal cells in BCC and SCC was statistically different [p < 0.001]. These findings support CD10 expression as a differential marker for BCC and SCC. CD10 staining pattern is mostly tumoral in BCC and stromal for SCC
ABSTRACT
Many researchers have been more interested in inflammatory changes in tumor stroma recently. Recent studies have shown that mast cells are significantly increased in human skin basal cell carcinoma [BCC] and are associated with tumor aggressiveness. In this study, we compared the number of mast cell population expressing c-kit in the BCC samples and normal skin. We also evaluated the number of this cell type in infliltrative and noninfiltrative subtypes of this tumor. Tissue sections containing 30 cases of BCCs and 30 normal skins were prepared and after staining with c-kit were analyzed for the number of stromal mast cells. Our results indicate that the number of c-kit positive mast cells was significantly higher in BCC when compared with normal skin [P<0.01], and number of mast cells in the stroma of infiltrative subtypes of this tumor is higher than noninfiltrative subtypes [p<0.04]. In our study there wasn't any correlation between sex and age with mast cells count. Our results are in line with previous studies indicating that mast cell numbers are increased in BCC. In addition, the results suggest that mast cell populations may contribute to BCC progression. Besides, we demonstrated that this increase in mast cell density was independent of the patient's ages and sexes